![]() The etiology of ADHD is not clear, but several lines of evidence imply that dopaminergic neurotransmission is impaired in ADHD ( 1). The disorder is characterized by a triad of inattention, impulsivity, and hyperactivity symptoms, as well as alterations in executive functioning. Ferritin levels and iron deficiency were not associated significantly with outcomes.Īttention deficit hyperactivity disorder (ADHD) is one of the most common pediatric psychiatric disorders. ![]() Logistic regression analysis showed that subjects with comorbid ODD/CD and LD were less likely to respond to treatment. ![]() The most frequent comorbidity was Oppositional Defiant Disorder/Conduct Disorder (ODD/CD, 51.6%), followed by Learning Disabilities (LD, 35.4%) and Anxiety Disorders (AD, 15.9%). Only 60 (17.4%) of the subjects had no comorbid disorders, while 38.3% had one comorbid disorder, 32.8% had two comorbid disorders, and 11.6% had three or more comorbid disorders. Two hundred and seventy eight (80.6%) subjects had combined subtype ADHD and the remainder had predominantly hyperactive-impulsive subtype. More than half (52.5%) of the subjects were previously drug-naive at treatment inception. The mean±sd of OROS-MPH and IR-MPH doses were 28.8☘.1 and 20.9☗.1 mg, respectively. A total of 255 (73.9%) patients were on OROS-methylphenidate (OROS-MPH) and 90 (26.1%) were on immediate release methylphenidate (IR-MPH).
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